Antidotes and the clinical applications pdf
Who gets antidotes? choosing the chosen fewAn understanding of mechanisms, potential benefits and risks of antidotes is essential for clinicians who manage poisoned patients. Of the dozens of antidotes currently available, only a few are regularly used. These include activated charcoal, acetylcysteine, naloxone, sodium bicarbonate, atropine, flumazenil, therapeutic antibodies and various vitamins. Even then, most are used in a minority of poisonings. There is little randomized trial evidence to support the use of most antidotes.
Who gets antidotes? choosing the chosen few
Cliniccal Emerg Med ; 51 : -5, 5 e1. The use of high doses of antidotes has implications for drug supply and staff training. This article needs additional citations for verification. Survival after a severe iron poisoning treated with intermittent infusions of deferoxamine.
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Drug Safety. Poisonings are a common problem. In , over 2 million exposures were reported to American poison information centres alone. The majority of poisoning exposures can be treated without major therapeutic intervention. If therapy is indicated, it is usually in the form of gastrointestinal decontamination with activated charcoal, to prevent absorption of the toxin and the subsequent toxicity that may occur.
Isoniazid overdose treated with highdose pyridoxine. For example, the poison aconitine - a highly poisonous alkaloid derived from various aconite species - has no antido. Appications H. Digoxin Immune Fab antibody Digibind and Digifab. John College of Pharmacy.
Poisonings are a common problem. In , over 2 million exposures were reported to American poison information centres alone. The majority of poisoning exposures can be treated without major therapeutic intervention. If therapy is indicated, it is usually in the form of gastrointestinal decontamination with activated charcoal, to prevent absorption of the toxin and the subsequent toxicity that may occur. In a limited number of cases, more aggressive life-support measures may be necessary to treat the adverse effects of poisons.
Many diagnoses result almost automatically in a series of treatments! Paracetamol acetaminophen poisoning. The concept is an appealing one: for every poison there really should exist an antidote. Antidote 1.
Digitalis and allied cardiac glycosides. Sensory neuropathy from pyridoxine abuse. Abolishing vagal effects and vasoconstriction are favourable for most drugs. Successfully reported this slideshow.